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采用改良的大鼠同种异体心肺联合移植手术，研究了大鼠树突状细胞（ＤＣｓ）单克隆抗体单独和联合雷公藤多甙片对移植排斥反应的影响，并与生理盐水对照组、雷公藤多甙片（ＴⅡ）组进行比较。结果表明：大鼠ＤＣｓ单抗单独和联合ＴⅡ两治疗组间无明显区别，但两组大鼠移植心脏存活时间明显长于生理盐水组和ＴⅡ组（Ｐ＜００１）；而且病理切片显示以慢性排斥反应改变为主。而生理盐水对照组和ＴⅡ组皆表现为急性排斥反应。提示ＤＣ单抗在治疗移植排斥反应中有实用价值。
Using modified rat allogeneic cardiopulmonary combined transplantation, the effect of single and combined tripterygium polyglucose dendritic cells (DCs) on graft rejection was studied and compared with saline control group, Teng polyglycoside tablets (T Ⅱ) group for comparison. The results showed that there was no significant difference between the DCs monoclonal antibody and TⅡ alone, but the survival time of cardiac allografts in the two groups were significantly longer than those in the saline group and the TⅡ group (P <0.01) Chronic rejection changes mainly. The saline control group and T Ⅱ group all showed acute rejection. It is suggested that DC monoclonal antibody has practical value in the treatment of transplant rejection.