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目的研究新方法合成N-取代-5-乙酰胺甲基-2-(?)唑烷酮。方法用苯甲醛作氨基保护剂,使环氧氯丙烷经氨解、环化两步反应后,生成中间体3-乙酰胺基-1,2-环氧丙烷。然后用氮取代氨基甲酸乙酯和中间体在催化剂存在下反应生成N-取代-5-乙酰胺甲基-2-(?)唑烷酮。结果合成了4种新化合物;3步反应总产率可达到50%;用IR,~1H NMR和元素分析表征了目标化合物的结构。结论反应条件温和,简便易行,是合成N-取代-5-乙酰胺甲基-2-(?)唑烷酮较好的方法。
Aim To study a new method for the synthesis of N-substituted-5-acetamidomethyl-2- (?) Oxazolidinones. The method uses benzaldehyde as the amino protecting agent to make the epichlorohydrin undergo aminolysis and cyclization to form the intermediate 3-acetamido-1,2-propylene oxide. Nitrogen substituted urethanes and intermediates are then reacted in the presence of a catalyst to form N-substituted-5-acetamidomethyl-2- (?) Oxazolidinones. Results Four new compounds were synthesized. The total yield of the three-step reaction reached 50%. The structures of target compounds were characterized by IR, 1H NMR and elemental analysis. Conclusion The reaction conditions are mild, simple and easy to synthesize N-substituted-5-acetamidomethyl-2- (?) Oxazolidinone better method.