有证据表明组织胺在癌症中起重要作用,一些肿瘤细胞存在有功能的组织胺受体。通过与某些和抗雌激素受体有关的细胞间受体结合,组织胺可作为乳癌细胞增殖的介质。已发现在各种实体肿瘤周围存在大量的肥大细胞,这种肥大细胞的数量对评价结直肠癌预后有一定价值。在各种动物模型和体外实验中,组织胺合成酶的特殊抑制剂组氨酸脱羧酶可抑制肿瘤生长,提示组织胺的合成可刺激肿瘤生长。组胺酸脱羧酶活性可作为肿瘤的有丝分裂指数,而这种分裂指数在 There is evidence that histamine plays an important role in cancer, and some tumor cells have functional histamine receptors. Histamine can act as a medium for proliferation of breast cancer cells by binding to certain intercellular receptors associated with anti-estrogen receptors. It has been found that there are a large number of mast cells around various solid tumors, and the number of such mast cells has a certain value for evaluating the prognosis of colorectal cancer. In various animal models and in vitro experiments, histidine decarboxylase, a special inhibitor of histamine synthase, inhibits tumor growth, suggesting that histamine synthesis stimulates tumor growth. Histidine decarboxylase activity can be used as a mitotic index of tumors, and this splitting index is