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目的观察熊去氧胆酸联合莫沙必利、铝碳酸镁治疗原发性胆汁反流性胃炎的临床疗效。方法将46例原发性胆汁反流性胃炎患者随机分成两组。治疗组22例给予熊去氧胆酸5 mg,每晚睡前口服一次;莫沙必利饭前半小时吞服,5 mg/次,3次/d;铝碳酸镁餐后1 h嚼服,1 g/次,3次/d,联合治疗4周。对照组24例采用莫沙必利、铝碳酸镁治疗4周。观察两组治疗前后主要临床症状包括上腹痛、腹胀、恶心、口苦等缓解情况。结果与对照组相比,治疗组主要临床症状缓解情况优于对照组(P<0.05)。疗程中各组均未见明显药物不良反应。结论熊去氧胆酸联合莫沙必利、铝碳酸镁治疗原发性胆汁反流性胃炎的疗效较好。
Objective To observe the clinical efficacy of ursodeoxycholic acid combined with mosapride and magnesium aluminum carbonate in the treatment of primary bile reflux gastritis. Methods 46 cases of primary bile reflux gastritis were randomly divided into two groups. 22 cases in the treatment group were given ursodeoxycholic acid 5 mg orally once a night before going to bed; mosapride swallowed half an hour before meals, 5 mg / time, 3 times / d; 1 g / time, 3 times / d, combined treatment for 4 weeks. 24 cases in the control group were treated with mosapride and aluminum magnesium carbonate for 4 weeks. Before and after treatment, the main clinical symptoms including abdominal pain, abdominal distension, nausea and mouth pain were observed. Results Compared with the control group, the alleviation of the main clinical symptoms in the treatment group was better than that in the control group (P <0.05). During the course of treatment, no obvious adverse drug reaction was observed in all the groups. Conclusion Ursodeoxycholic acid combined with mosapride, magnesium aluminum carbonate treatment of primary bile reflux gastritis better effect.