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目的探讨糖尿病患者血清胱抑素C(Cys C)、尿α1-MG及β2-MG水平对肾损伤早期诊断价值。方法采用免疫比浊法检测血清Cys C、尿α1-MG及β2-MG水平。统计学处理采用SPSS统计学软件,组间比较用t检验,P<0.05为差异有统计学处理。结果糖尿病患者血清Cys C、尿α1-MG及β2-MG水平均显著高于对照组(P<0.05),单纯检测一项或两项指标阳性率较低,而联合检测则能提高阳性率。结论本研究表明血清Cys C、尿α1-MG及β2-MG能准确反映肾小球滤过功能,能敏感提示早期肾功能损害,可成为判断肾功能损害程度的敏感指标。
Objective To investigate the value of serum cystatin C (Cys C), urinary α1-MG and β2-MG in the early diagnosis of renal injury in diabetic patients. Methods Serum levels of Cys C, urinary α1-MG and β2-MG were measured by immunoturbidimetry. Statistical analysis using SPSS statistical software, t test between groups, P <0.05 for the difference was statistically significant. Results Serum levels of Cys C, urinary α1-MG and β2-MG in diabetic patients were significantly higher than those in the control group (P <0.05). The positive rate of one or two indexes was lower in patients with diabetes mellitus. Conclusions This study shows that serum Cys C, urinary α1-MG and β2-MG can accurately reflect glomerular filtration function, and can sensitively indicate early renal dysfunction and may be a sensitive index to judge the degree of renal damage.