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目的 :研究肿瘤病人化疗前后常规肾功能指标与早期肾功能损害指标的变化及临床意义。方法 :对 4 3例患者在第一周期化疗前 (D0 )、化疗后第 7天 (D7)、化疗后第 14天 (D14 )、化疗后第 2 8天 (D2 8)四个时点检测尿常规 ,血尿素氮 ,血肌酐 ,血尿酸以及尿NAG ,尿RBP ,尿AIB和尿 β2 -MG。结果 :常规肾功能指标和尿AIB在各种分组条件下四时点比较均没有统计学差异 ;NAG在D7的均值高于D0 (P =0 .0 2 1) ;β2 -MG治疗前后有统计学差异 (P =0 .0 0 6 ) ;化疗后RBP均显著升高。结论 :常规肾功能指标不能反映化疗引起的早期肾损伤 ,常规化疗可引起尿RBP和尿 β2 -MG值升高 ,但不影响下周期化疗
Objective: To study the changes and clinical significance of routine renal function indexes and early renal dysfunction indexes in cancer patients before and after chemotherapy. Methods: Forty-three patients were examined at four time points before chemotherapy (D0), on the 7th day after chemotherapy (D7), on the 14th day after chemotherapy (D14) and on the 28th day after chemotherapy (D2 8) Urinary routine, blood urea nitrogen, serum creatinine, serum uric acid and urine NAG, urine RBP, urinary AIB and urinary β2 -MG. Results: There was no statistic difference between routine renal function indexes and urinary AIB in four groups at different grouping conditions. The average value of NAG in D7 was higher than that in D0 (P = 0.021); there was statistics before and after treatment with β2-MG The difference was significant (P = 0.060). The RBP after chemotherapy was significantly increased. CONCLUSION: Conventional renal function indexes can not reflect the early renal damage caused by chemotherapy. Conventional chemotherapy can cause the urinary RBP and urinary β2-MG values to increase, but not affect the next cycle chemotherapy