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目的观察六郁同治法对不稳定型心绞痛实证患者的临床疗效。方法将60例不稳定心绞痛患者随机分为2组,六郁同治观察组(观察组)予六郁同治方+西医常规治疗,对照组予通心络+西医常规治疗,疗程为4周。观察2组患者治疗前后中医症状评分、证候疗效、心绞痛疗效、心电图变化、血脂、血清hsCRP、MMP-9及安全性指标变化。结果观察组心绞痛、中医证候疗效均高于对照组,差异有统计学意义(P<0.05)。治疗后2组TC、TG、LDL-C、HDL-C、hsCRP表达、MMP-9表达均较治疗前改善,差异有统计学意义(P<0.05);观察组较对照组改善更明显,差异有统计学意义(P<0.05)。结论六郁同治法治疗不稳定心绞痛安全有效,作用机制可能与调节脂代谢、抑制hsCRP及MMP-9表达相关。
Objective To observe the clinical efficacy of Liuyu Tongzhi method in patients with unstable angina pectoris. Methods Sixty patients with unstable angina pectoris were randomly divided into two groups. The observation group of Liuyu Tongzhi (observation group) was treated with Liuyu Tongzhi prescription + western medicine routinely. The control group was treated with Tongxinluo + western medicine routinely for 4 weeks. The TCM symptom score, the curative effect of syndrome, the curative effect of angina pectoris, electrocardiogram changes, blood lipid, serum hsCRP, MMP-9 and safety index before and after treatment were observed in two groups of patients. Results The observation group angina pectoris, TCM syndrome curative effect were higher than the control group, the difference was statistically significant (P <0.05). The levels of TC, TG, LDL-C, HDL-C, hsCRP and MMP-9 in the two groups after treatment were significantly improved compared with before treatment (P <0.05), and the improvement in the observation group was more obvious than that in the control group There was statistical significance (P <0.05). Conclusions Liuyu Tongzhi Therapy is safe and effective in the treatment of unstable angina pectoris. The mechanism may be related to the regulation of lipid metabolism, inhibition of hsCRP and MMP-9 expression.