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目的探讨内脂素(visfatin)与体质量指数(BMI)、血脂[甘油三酯(TG)、总胆固醇(TC)]、胰岛素抵抗(IR)的关系。方法采用电化学发光法和酶联免疫吸附法(ELISA)以及全自动生化仪分别测定52例妊娠期糖尿病孕妇(GDM组)和52例糖耐量正常孕妇(NGT组)的空腹血糖(FPG)、空腹胰岛素(FINS)、visfatin水平。计算BMI和胰岛素抵抗指数(IRI)。结果 1 GDM组孕妇BMI明显高于NGT组,差异有统计学意义(P<0.05)。2 GDM组孕妇TG高于NGT组,差异有统计学意义(P<0.05);两组孕妇TC比较差异无统计学意义(P>0.05)。3 GDM组孕妇FPG、FINS、visfatin、IRI均高于NGT组,差异有统计学意义(P<0.05)。结论 GDM孕妇血清visfatin水平明显升高,与机体针对甘油三酯升高和胰岛素抵抗产生的代偿反应有关。
Objective To investigate the relationship between visfatin and body mass index (BMI), serum lipids (triglyceride (TG), total cholesterol (TC)] and insulin resistance (IR). Methods The levels of fasting blood glucose (FPG) in 52 pregnant women with gestational diabetes mellitus (GDM group) and 52 normal pregnant women with NGT (NGT group) were measured by electrochemiluminescence and enzyme-linked immunosorbent assay (ELISA) Fasting insulin (FINS), visfatin levels. BMI and Insulin Resistance Index (IRI) were calculated. Results The BMI of pregnant women in 1 GDM group was significantly higher than that of NGT group, the difference was statistically significant (P <0.05). The TG of pregnant women in 2 GDM group was higher than NGT group, the difference was statistically significant (P <0.05). There was no significant difference in TC between the two groups (P> 0.05). The FPG, FINS, visfatin and IRI in 3 GDM group were significantly higher than those in NGT group, the difference was statistically significant (P <0.05). Conclusion Serum visfatin levels in pregnant women with GDM are significantly increased, which are related to the compensatory response to elevated triglycerides and insulin resistance.