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系统性红斑狼疮(SLE)患者的表皮基底膜上有各种免疫球蛋白和补体成分等沉着,但还没有见到免疫球蛋白E(IgE)沉着的报导。在免疫球蛋白中,一般认为IgE与先天过敏性疾病,特别是与即刻过敏反应型疾病有密切关系。关于SLE,最近相继有报告发表,认为在病情发展期,血清中的免疫球蛋白E浓度升高,而与血中抗核抗体的变动相一致,另外,有IgE抗核抗体的患者,肾病变化发生恶化的情况较之皮疹要多,因此IgE和SLE的关系受到人们重视。作者证明IgE在SLE的皮损及健康皮肤上均有沉着。其情况:1.表皮基底膜上:7例SLE患者中5例IgE为阳性,荧光类型呈现颗粒状或细颗粒状,沿表皮基底膜可以看到有连续性的分布,2.血管上:7例中4例为阳性,发现在真皮毛细血管甚至小血管上。3.表皮细胞核:仅1例在表
Patients with systemic lupus erythematosus (SLE) have a variety of immunoglobulin and complement components on the epidermal basement membrane, but no evidence of immunoglobulin E (IgE) sedation has been reported. Among immunoglobulins, IgE is generally considered to be closely related to innate allergic diseases, especially those with immediate allergic reaction. About SLE, recently published reports, that in the progression of the disease, the serum immunoglobulin E concentration increased, and changes in blood anti-nuclear antibodies consistent, in addition, IgE antinuclear antibodies in patients with kidney disease changes The deterioration occurs more than the rash, so the relationship between IgE and SLE by people attention. The authors show that IgE is sedate on both SLE lesions and healthy skin. The situation: 1. Epidermal basement membrane: 5 cases of IgE positive in 7 cases of SLE patients, the type of fluorescence showed granular or fine granular along the epidermal basement membrane can be seen in a continuous distribution, 2. On the blood vessels: 7 4 cases were positive, found in the dermal capillaries and even small blood vessels. 3. Epidermal nuclei: only 1 case in the table