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我们用放射免疫分析（ＲＩＡ）测定了２５名健康志愿者和２８例急性脑卒中病人（脑出血１２例、脑梗塞１６例）血浆内皮素（ＥＴ）、心钠素（ＡＮＰ）和血管紧张素Ⅱ（ＡＴⅡ）的含量。急性脑卒中病人的血浆ＥＴ、ＡＴⅡ均高于正常对照（Ｐ＜０．０１），ＡＮＰ含量则低于正常对照（Ｐ＜０．０１），脑出血与脑梗塞患者血浆上述指标差异不明显。同时发现基底节区病变者血浆ＥＴ虽然比正常高，但无统计学意义，而大脑皮层和其它部位病变者则明显高于正常对照（Ｐ均＜０．０１），且血浆ＥＴ和ＡＴⅡ均与ＡＮＰ成负相关（ｒ＝－０．４８和－０．４７，Ｐ＜０．０１），血浆ＥＴ和ＡＴⅡ之间成正相关（ｒ＝０．５６，Ｐ＜０．０１）．结果提示，ＥＴ与急性脑卒中病人的发病及部位有关，且与血管活性多肽（如ＡＮＰ、ＡＴⅡ）之间存在明显的相关性。
We measured plasma endothelin (ET), atrial natriuretic peptide (ANP), and angiotensin (ALP) levels in 25 healthy volunteers and 28 acute stroke patients (12 with cerebral hemorrhage and 16 with cerebral infarction) using radioimmunoassay (RIA) Ⅱ (AT Ⅱ) content. The levels of plasma ET and ATⅡ in patients with acute stroke were significantly higher than those in normal controls (P <0.01), while those in ANP were lower than those in normal controls (P <0.01). There was no significant difference between the above indexes in patients with cerebral hemorrhage and cerebral infarction. Also found that patients with basal ganglia lesions plasma ET although higher than normal, but no statistical significance, while the cerebral cortex and other parts of the lesions were significantly higher than the normal control (P all <0.01), and plasma ET and AT Ⅱ were ANP (r = -0.48 and -0.47, P <0.01). There was a positive correlation between plasma ET and ATⅡ (r = 0.56, P <0.01). The results suggest that ET is associated with the pathogenesis and location of patients with acute stroke, and there is a clear correlation between ET and vasoactive peptides (such as ANP, AT Ⅱ).