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目的通过新生儿神经行为测定(NBNA)及脑干听觉诱发电位(BAEP)探讨神经节苷脂治疗中重度新生儿缺氧缺血性脑病的疗效。方法将58例中重度HIE患儿随机分为治疗组(GM1,n=30)和对照组(胞二磷胆碱,n=28)。两组分别在生后第2天、15天、28天进行新生儿神经行为能力测定(NBNA)及脑干听觉诱发电位检测(BAEP)。结果治疗前两组NBNA评分及BAEP异常率均无明显差异(P>0.05);治疗后GM1组NBNA评分高于对照组(P<0.05,P<0.01);BAEP异常率低于对照组(P<0.05,P<0.01)。结论GM1治疗中、重度新生儿H IE疗效理想;NB-NA及BAEP可作为GM1治疗新生儿HIE疗效评价的重要指标。
Objective To evaluate the efficacy of gangliosides in the treatment of moderate-severe hypoxic-ischemic encephalopathy (HIE) by neonatal neurobehavior test (NBNA) and brainstem auditory evoked potentials (BAEP). Methods 58 cases of moderate and severe HIE were randomly divided into treatment group (GM1, n = 30) and control group (Citicoline, n = 28). Neonatal behavioral assessment (NBNA) and brainstem auditory evoked potential (BAEP) were performed on the 2nd, 15th and 28th day after birth in both groups. Results There was no significant difference in NBNA score and BAEP abnormality between the two groups before treatment (P> 0.05). After treatment, the NBNA score of GM1 group was higher than that of control group (P <0.05, P <0.01); the abnormal rate of BAEP was lower than that of control group <0.05, P <0.01). Conclusion GM1 treatment, severe neonatal H IE ideal effect; NB-NA and BAEP can be used as GM1 treatment of neonatal HIE curative effect evaluation of the important indicators.