乳腺癌作为一种激素依赖性实体瘤,它的发生与肿瘤细胞凋亡受阻有关。Fas/Fas L在乳腺癌细胞凋亡中起重要作用,它们在乳腺癌的诊断、治疗及预后方面有很高的临床应用价值。生存素Survivin是凋亡抑制蛋白(inhibitors of apoptosis proteins,IAPs)家族的新成员,参与调控细胞的增殖和凋亡,在人类多种恶性肿瘤中,Survivin高表达并提示预后不良。奉研究对Fas/Fas L和Survivin与乳腺癌的关系研究进展加以综述。 Breast cancer as a hormone-dependent solid tumor, its occurrence and tumor cell apoptosis related to obstruction. Fas / Fas L plays an important role in the apoptosis of breast cancer cells, and they have high clinical value in the diagnosis, treatment and prognosis of breast cancer. Survivin, a new member of the inhibitors of apoptosis proteins (IAPs) family, is involved in the regulation of cell proliferation and apoptosis. Survivin is highly expressed in many human malignancies and suggests a poor prognosis. In the study of the relationship between Fas / Fas L and Survivin and breast cancer research are reviewed.