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目的：将骨形态形成蛋白用于大面积关节软骨缺损的修复，探讨应用方法，观察修复效果。方法：在51只成年兔股骨的髌髁关节面上制造5mm×10mm的骨软骨缺损，深3～5mm。缺损内分别填充骨形态形成蛋白和纤维蛋白粘合剂复合物（BMP／FS）、BMP、FS，植入物均用自体游离骨膜覆盖。术后2、4、8、12周对缺损修复情况行大体和组织学观察。结果：BMP／FS组，8周时软骨下骨再生已完成，12周表层新生软骨组织结构接近正常，修复效果明显优于其它组。结论：骨膜覆盖固定BMP／FS，是修复大面积关节软骨缺损的较好方法。
OBJECTIVE: To use bone morphogenetic protein to repair large area articular cartilage defects and to explore the application methods to observe the effect of repair. Methods: The osteochondral defects of 5mm × 10mm were made on the surface of the patellar condyle of 51 adult rabbit femurs, 3 ~ 5mm deep. The defects were filled with bone morphogenetic protein and fibrin adhesive composite (BMP / FS), BMP, FS, implants were covered with autologous free periosteum. At 2, 4, 8 and 12 weeks after operation, the general and histological observation of the defect was performed. Results: Under the condition of BMP / FS, the regeneration of subchondral bone was completed at 8 weeks. The structure of newborn cartilage in the surface of 12 weeks was close to normal, and the repair effect was better than other groups. CONCLUSION: Periosteal coverage of fixed BMP / FS is a good method to repair large area articular cartilage defects.