口腔感染性疾病多由厌氧菌所致，而无芽胞厌氧菌通常是牙周炎和冠周炎的病原体[1－3]。一些常用的抗生素如青霉素类、氨基糖甙类对厌氧菌的疗效较差[4]。阿齐霉素（Azrtbromycin）系第三代大钙内酯类抗生素，是有抗菌谱广，抗菌作用，强副作用小和不易产生财药性等优点，但价格 Oral infectious diseases are mostly caused by anaerobic bacteria, while non-spore-forming anaerobes are usually the pathogens of periodontitis and pericentritis [1-3]. Some commonly used antibiotics such as penicillins, aminoglycosides on the poor efficacy of anaerobic bacteria [4]. Azithromycin (Azrtbromycin) is the third generation of large calcium lactone antibiotics, antibacterial spectrum is broad, antibacterial effect, strong side effects and not easy to produce financial and other advantages, but the price