本文应用透射电镜观察1例毛细胞白血病,经用小剂量(1.5×10~4单位/日×27天)人白细胞干扰素治疗后的骨髓细胞超微结构改变,发现该药对毛细胞的损伤主要表现为核周间隙扩大,核膜崩解,糙面内质网扩大、泡状化及出现髓样结构等。对粒细胞系统及红细胞系统也有类似轻微改变。 In this paper, transmission electron microscopy was used to observe a case of hairy cell leukemia. The ultrastructural changes of bone marrow cells after treatment with low dose (1.5 × 10 ~ 4 units / day × 27 days) human leukocyte interferon and found that the drug damage to hair cells Mainly for the expansion of the perinuclear space, disintegration of the nuclear membrane, rough endoplasmic reticulum, vesicular changes and the emergence of medullary structures. There are also minor changes to the granulocyte and erythrocyte systems.