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目的 研究健康老年人脑的功能性和结构性影像学特征。方法 将 73名年龄≥ 6 0岁的健康志愿者按年龄分为 6 0～ 6 5岁组 (第 1组 )、6 6～ 70岁组 (第 2组 )和 >70岁组 (第 3组 ) ,采用单光子发射计算机体层摄影术对 3组进行脑组织检查 ,并对其中的 2 9名自愿者进行脑磁共振显像检查。结果 (1)经方差分析 ,第 2组和第 3组脑组织几乎所有部位 (除右丘脑和扣带回外 )的灌注均低于第 1组 ,其中第 2组右顶叶灌注的放射性计数比值 (RAR)为 0 87± 0 18,低于第 1组 (RAR =0 98±0 17;P <0 0 1) ;(2 )经配对t检验 ,除第 2组的双侧顶叶外 ,3组颞叶和顶叶的灌注均为右侧高于左侧(P <0 0 1和 0 0 5 ) ;(3)经方差分析 ,第 3组的灰质体积占颅内容积的百分比 [(47 5 9± 1 2 6 ) % ]小于第 2组 [(49 43± 1 30 ) % ],总脑脊液体积占颅内容积的百分比 [(14 6 1± 3 16 ) % ]大于第 1组[(12 41± 0 73) % ]和第 2组 [(11 94± 1 2 7) % ],右侧海马体积 [(2 0 4± 0 2 3)cm3 ]小于第 1组[(2 2 7± 0 2 0 )cm3 ],P均 <0 0 5。结论 健康老年人在脑血流灌注方面 ,存在颞顶叶灌注双侧不对称 ,右侧高于左侧 ,>6 5岁者以右顶叶的降低为著 ;在脑结构性变化方面 ,>70岁者以灰质、右侧海马体积缩小和总脑脊液体
Objective To study the functional and structural imaging features of the brain in healthy elderly. Methods A total of 73 healthy volunteers aged 60 years or older were divided into groups of 60 to 65 years old (group 1), groups 6 to 70 (group 2) and group 70 (group 3) ), Using single photon emission computed tomography for brain tissue examination of 3 groups, and 29 of them were brain magnetic resonance imaging examination. Results (1) By ANOVA, perfusion in almost all parts of brain tissue in Group 2 and Group 3 (except the right thalamus and cingulate gyrus) was lower than that in Group 1, and the radiological counts of right parietal lobe perfusion in Group 2 (RAR) was 0 87 ± 0 18, which was lower than that of group 1 (RAR = 0 98 ± 0 17; P 0 01). (2) Paired t- , 3 groups of temporal lobe and parietal lobe perfusion were higher right than the left (P <0.01 and 0 0 5); (3) analysis of variance, the third group of gray matter volume accounted for the percentage of intracranial volume [ (47 59 ± 126)%] was lower than that in group 2 [(49 43 ± 1 30)%], and the percentage of total cerebrospinal fluid volume to intracranial volume was (14 6 1 ± 3 16)%] [(12 41 ± 0 73)%] and group 2 [(11 94 ± 1 27)%], and volume of right hippocampus [(20 4 ± 0 2 3) cm 3] 7 ± 0 2 0) cm3], all P <0 05. Conclusion In cerebral hemorrhage, there is bilateral asymmetry of temporal parietal perfusion in right elder than in left elder, and the reduction of right parietal lobe in> 65 years old in healthy elders. In structural changes of brain, 70-year-old with gray matter, the right side of the hippocampus and the total cerebrospinal fluid volume reduction