非甾体抗炎药(NSAID,Nosteroidal Antiinflam-matory Drug)在临床上广泛用于解热、镇痛、抗炎。在我国药品生产中是仅次于抗生素的第二大类药。其胃肠道副作用多见,NSAID对肾脏的损害也逐渐为人们所重视。NSAID通过对肾血流和肾小球滤过作用以及细胞免疫导致肾功能衰竭、水电解质紊乱。长期服用止痛剂及其合剂可引起止痛剂肾病,不同NSAID对肾功能损害也不尽相同,本文就NSAID对肾脏损害作以下概述。 Non-steroidal anti-inflammatory drugs (NSAIDs, Nosteroidal Antiinflam-matory Drug) are widely used clinically antipyretic, analgesic, anti-inflammatory. In China’s pharmaceutical production is second only to antibiotics, the second largest category of drugs. More common gastrointestinal side effects, damage to the kidneys NSAID also gradually as people pay attention. NSAID through renal blood flow and glomerular filtration and cellular immunity lead to renal failure, water and electrolyte imbalance. Long-term use of analgesics and their mixture can cause analgesic nephropathy, different NSAID damage to renal function are not the same, this article on the NSAID kidney damage in the following overview.