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[目的]探讨异体输血对消化道出血患者凝血功能及部分免疫功能的影响。[方法]入选消化性溃疡出血、血红蛋白65~75g/L的患者40例,其中不给予输血治疗20例作为对照组,给予输注少白红细胞2~4U的20例作为输血组,并分别于输血组的输血前、输血后采取2组患者静脉血,检测其凝血功能及外周血中自然杀伤(NK)细胞、IgG、IgA、IgM、CD3~+、CD4~+、CD8~+、CD4~+/CD8~+的变化情况。[结果]输血组输血前与对照组各项指标均无显著差异,输血后NK细胞、CD3~+、CD4~+、CD4~+/CD8~+、IgG较输血前显著减少(P<0.05),IgA、IgM与输血前变化不显著;输血组输血前、输血后1d凝血功能指标变化均差异不显著(P>0.05)。[结论]异体输血对纠正患者失血性贫血有疗效,但对患者免疫功能抑制明显,对于异体输血量在一定范围内的患者凝血功能无明显影响。
[Objective] To investigate the effect of allogeneic blood transfusion on coagulation function and partial immune function in patients with gastrointestinal hemorrhage. [Methods] Forty patients with peptic ulcer hemorrhage and hemoglobin 65 ~ 75g / L were enrolled in this study. Twenty patients without blood transfusion were used as the control group, and 20 patients with 2 ~ 4U transfused leucocytes were given as blood transfusion group. Before blood transfusion in blood transfusion group, venous blood was taken from 2 groups of patients after blood transfusion to test its coagulation function and the activity of natural killer (NK) cells, IgG, IgA, IgM, CD3 +, CD4 +, CD8 + + / CD8 ~ + changes. [Results] There was no significant difference between the transfusion group and the control group before transfusion. The levels of CD3 +, CD4 +, CD4 + / CD8 +, and IgG in the blood transfusion group were significantly lower than those before transfusion (P <0.05) , IgA, IgM and blood transfusion before the change was insignificant; blood transfusion blood transfusion before and after 1 d blood coagulation function changes were not significantly different (P> 0.05). [Conclusion] Allogeneic blood transfusion is effective in correcting hemorrhagic anemia in patients, but it has obvious inhibitory effect on immune function. It has no obvious effect on coagulation function in patients with allogeneic transfusion volume.