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目的 :探讨选择性凋亡在戊四氮所致慢性癫疒间形成中的作用。方法 :采用免疫组化及原位末端标记双标技术观察海马γ 氨基丁酸 (GABA)能神经元、谷氨酸 (Glu)能神经元各自凋亡情况。结果 :GABA能神经元凋亡数明显高于Glu能神经元凋亡数 ,两者比较有显著性差异。结论 :在癫形成期间脑内可能通过某种机制引发了细胞程序性死亡过程 ,选择性地引起GABA能神经元凋亡占优势 ,打破了兴奋与抑制性神经递质之间的平衡 ,从而促发癫
Objective: To explore the role of selective apoptosis in the formation of chronic epilepsy induced by pentylenetetrazole. Methods: Apoptosis of GABAergic neurons and glutamatergic neurons in hippocampus were observed by immunohistochemistry and double-labeled in situ end-labeling. Results: The number of apoptosis of GABAergic neurons was significantly higher than that of Glu neurons. There was a significant difference between the two. CONCLUSION: During the process of epilepsy, the brain may initiate programmed cell death through a mechanism that selectively induces apoptosis in GABAergic neurons and breaks the balance between excitability and inhibitory neurotransmitters, thus Promote epilepsy