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目的：了解并比较生长抑素（ＳＳ）、胃动素（ＭＴＬ）在人胚胎消化系统发生、发展及分布的规律。方法：应用放射免疫分析法（ＲＩＡ）系统测定１５例人胎儿消化道各部位ＳＳ及ＭＴＬ的组织含量。结果：在人胚胎胃肠道组织中均有不同浓度的ＳＳ和ＭＴＬ存在，ＳＳ在消化道出现的时间均早于１６周；ＭＴＬ除食管、贲门、幽门、盲肠、阑尾晚于２２周，其余均早于１６周。各部位ＳＳ含量以十二指肠、胃较高，与其它部位比较Ｐ＜０．０５，而ＭＴＬ以空肠、十二指肠为高（Ｐ＜０．０５）。随胚胎发育，ＳＳ的发展呈不同趋势：①胃、十二指肠、空肠ＳＳ持续升高，且胃、十二指肠ＳＳ浓度与胎龄呈正相关（ｒ＝０．８０７７；ｒ＝６７９３；Ｐ＜０．０１）；②食管、回肠、结肠ＳＳ波动在一定水平，变化无显著性差异（Ｐ＞０．０５）；③贲门、幽门、盲肠、阑尾ＳＳ则呈下降趋势，阑尾ＳＳ与胎龄呈负相关（ｒ＝－０．７８８９；Ｐ＜０．０１）；而ＭＴＬ各部位水平随胚胎发育呈一致性升高，空肠、十二指肠ＭＴＬ与胎龄呈正相关（ｒ＝０．８１２５，ｒ＝０．７７３４，Ｐ＜０．０１）。结论：ＳＳ与ＭＴＬ在人胎儿胃肠道中的发生、发展及分布存在不同规律
Objective: To understand and compare the occurrence, development and distribution of somatostatin (SS) and motilin (MTL) in human embryo digestive system. Methods: The radioimmunoassay (RIA) system was used to determine the content of SS and MTL in 15 cases of human fetal digestive tract. Results: There were SS and MTL in different concentrations in human embryo gastrointestinal tissue. SS occurred in digestive tract earlier than 16 weeks. MTL except esophagus, cardia, pylorus, cecum and appendix were later than 22 weeks. All earlier than 16 weeks. The contents of SS in each part were higher in the duodenum and stomach, P <0.05 compared with other parts, while MTL was higher in jejunum and duodenum (P <0.05). With the development of embryos, the development of SS showed different trends: (1) Stomach, duodenum and jejunum SS continued to increase, and the gastric and duodenal SS concentrations were positively correlated with gestational age (r = 0.8077; r = 6793; (P> 0.05); ②The SS, esophageal, ileum and colon SS fluctuated at a certain level with no significant difference (P> 0.05) (R = -0.7889; P <0.01). However, the levels of various parts of MTL increased consistently with the embryonic development. The jejunum and duodenum showed a positive correlation with gestational age (r = -0.7889, P <0.01). 8125, r = 0.7734, P <0.01). Conclusion: The occurrence, development and distribution of SS and MTL in human fetal gastrointestinal tract have different rules