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采用反相悬浮乳液法合成了丙烯酸(AA)含量不同的N-异丙基丙烯酰胺(NIPAM)共聚丙烯酸(AA)的聚合物模板P(NIPAM-co-AA),以此作为微反应器,分别用两种不同的方法制备了P(NIPAM-co-AA)-co-Alq3(八羟基喹啉铝)荧光复合微球,再用四乙氧基硅烷(TEOS)对其表面进行修饰,获得了表面功能化的P(NIPAM-co-AA)-Alq3-SiO2荧光复合微球。用SEM、IR、FM和XRD等手段对其结构和性能进行表征。结果表明:所制备的荧光复合微球单分散性好、荧光发光效率较高且性能稳定,同时具有较大的比表面积;功能化的荧光复合微球可用于高通量药物筛选和识别生物大分子等生物医学领域。
The polymer template N (NIPAM-co-AA) with N-isopropylacrylamide (NIPAM) copolymerized acrylic acid (AA) with different content of acrylic acid (AA) was synthesized by reversed- P (NIPAM-co-AA) -co-Alq3 (octahydroxyquinoline aluminum) fluorescent composite microspheres were prepared by two different methods respectively, and then their surface was modified by tetraethoxysilane (TEOS) Surface functionalized P (NIPAM-co-AA) -Alq3-SiO2 fluorescent composite microspheres. Its structure and properties were characterized by SEM, IR, FM and XRD. The results showed that the prepared fluorescent composite microspheres had good monodispersity, high fluorescence luminescence efficiency, stable performance and large specific surface area. The functionalized fluorescent composite microspheres could be used in high-throughput drug screening and biological identification Molecular and other biomedical fields.