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顺铂(DDP)是目前联合化疗的主要药物之一DDP肾毒性是剂量限制的主要因素。近年来国内外对DDP肾毒性的防治进行了卓有成效的研究,使DDP动、静脉一次投药量提高到100～150mg/m~2、腔内灌注一次投约量提高到100～180mg/m~2、而肾毒性不明显。但临床上仍时有DDP所致的急性肾衰发生,对其原因值得进一步探讨。本文对发现的4例DDP所致急性肾衰死亡的原因进行厂分析,以期从中总结经验教训,进一步改善临床治疗工作。
Cisplatin (DDP) is one of the main drugs currently combined with chemotherapy DDP nephrotoxicity is the main factor of dose limitation. In recent years, the domestic and foreign research on the prevention and treatment of DDP nephrotoxicity has been carried out fruitful, so that the DDP arterial and venous once dosing increased to 100 ~ 150mg / m ~ 2, intraluminal perfusion once the amount of increase to 100 ~ 180mg / m ~ 2 , While nephrotoxicity is not obvious. However, there are still cases of acute renal failure caused by DDP in clinical practice, and its cause is worth further exploration. In this paper, we found 4 cases of acute renal failure caused by DDP-induced plant analysis, with a view to summarize the lessons learned to further improve the clinical treatment.