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目的 对胃癌高发区的西安地区城市及农村自然人群Hp及CasA~+HP感染状况进行血清流行病学调查,以期了解各年龄段Hp及CagA~+Hp感染状况以及与胃癌等胃疾病的关系, 方法 对胃癌高发区的西安地区城市及农村自然人群2134人及525例胃病患者进行现况调查,并使用斑点金免疫渗滤法(DIGFA)对被调查者末梢血血清行抗Hp-尿素酶IgG(抗HpU-IgG)及抗Hp-CagA-IgG检测,检测结果进行统计学处理,感染率用百分数表示,做X~2检验,P<0.05为差异有显著意义。 结果 我们首次采用DIGFA方法对胃癌高发地区的西安地区自然人群包括婴幼儿在内的大样本人群及胃病患者进行抗Hp-CagA-lgG及抗HpU-IgG的血清流行病学调查,显示了西安地区0岁～60岁Hp感染与CagA~+Hp感染年龄分布的全貌,其结果显示西安地区Hp感染的特点为:①可分为剧增期,缓增期,及平坦期,而且剧增期明显提前而且持续时间短(2岁～3岁年龄段),缓增期不明显,5岁～6岁己接近平坦期(Hp感染率达50％左右)。②西安地区Hp的平均感染率为54.1％(31.1％～65.7％),其中CagA~+Hp感染率占23.2％(12.5％～29.3％),城市及农村Hp与CagA~+Hp感染率差异无显著意义(x~2=0.01;2.85,P>0.05)。③自然人群各年龄组中CagA~+Hp感染率占Hp总感染率的比值相对固定,约为30％ ～50％。④各种胃病患者CagA~+
Objective To investigate the seroprevalence of Hp and CasA ~ + HP in urban and rural natural populations in high incidence area of gastric cancer in Xi’an, in order to understand the relationship between Hp and CagA ~ + Hp infection and gastric diseases such as gastric cancer, Methods The prevalence of 2134 and 525 cases of gastric patients in urban and rural areas with high prevalence of gastric cancer in urban and rural areas of Xi’an City was investigated. Dot immunogold filtration assay (DIGFA) was used to detect the levels of anti-Hp-urease IgG (Anti-HpU-IgG) and anti-Hp-CagA-IgG, the detection results were statistically analyzed, the infection rate was expressed as a percentage, do X ~ 2 test, P <0.05 for the difference was significant. Results We first conducted a serological epidemiological investigation of anti-Hp-CagA-lgG and anti-HpU-IgG anti-Hp-CagA-lgG and anti-HpU-IgG in large sample population and stomach patients in natural population including high infants with gastric cancer in Xi’an, The overall distribution of age-related Hp infection and CagA ~ + Hp infection in 0-year-old 60 years old showed that the characteristics of Hp infection in Xi’an were as follows: (1) It can be divided into the period of dramatic increase, gradual increase and flat, Early and short duration (2 years old to 3 years of age), the slow growth period is not obvious, 5 years old to 6 years old has been close to flat (Hp infection rate of about 50%). ② The average infection rate of Hp in Xi’an was 54.1% (31.1% -65.7%), of which CagA ~ + Hp infection rate was 23.2% (12.5% -29.3%). The infection rates of Hp and CagA ~ + Hp in urban and rural areas were no difference Significant (x ~ 2 = 0.01; 2.85, P> 0.05). (3) The ratio of CagA ~ + Hp infection rate to Hp infection rate in each age group was relatively fixed, about 30% ~ 50%. ④ various stomach patients CagA ~ +