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目的进一步探讨健肾片对慢性肾炎的疗效及作用机理。方法运用嘌呤霉素腹腔注射所致肾病大鼠病理模型。经用化学发光法检测实验动物的超氧阴离子，采用硝酸还原酶化学比色法检测ＮＯ含量。结果发现该药可减轻嘌呤霉素肾病大鼠的病理变化，减低模型动物的血和红细胞Ｏ－２含量，提高其ＮＯ含量。结论健肾片具有调整自由基反应和增加血ＮＯ的生物活性作用
Objective To further explore the efficacy and mechanism of Jianshen tablet on chronic nephritis. Methods The pathological model of nephropathy rats induced by intraperitoneal injection of puromycin was used. The superoxide anion in experimental animals was detected by chemiluminescence and NO content was determined by nitrate reductase chemical colorimetry. The results showed that the drug can reduce the pathological changes of puromycin nephropathy rats, reduce the blood and red blood cell O-2 content of model animals, and increase its NO content. Conclusion Jianshen tablet can regulate free radical reaction and increase the biological activity of blood NO