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目的 :研究实验动物对小儿热感宁口服液 (XRK)的毒性反应。方法 :分别给予小鼠临床剂量 30 0倍的 XRK(XRK组 )和维 C银翘片的混悬液 (阳性对照组 ) ,7天后观察小鼠的急性毒性反应 ;给予大鼠临床剂量 10倍 (XRK低剂量组 )和 10 0倍 (XRK高剂量组 )的 XRK,连续给药 14天后观察小鼠的长期毒性反应。结果 :在急性毒性试验中 ,XRK组及空白对照组 7天后无一死亡 ,主要组织基本正常 ,而阳性对照组死亡率达 90 % ,主要组织心、肝、肾出现明显损害 ;在长期毒性试验中 ,空白对照组、XRK低剂量组及 XRK高剂量组的大鼠均未发现异常和死亡。结论 :小儿热感宁口服液是一种比维 C银翘片安全、低毒的解热药。
Objective: To study the toxic effects of experimental animals on pediatric heat sensitive oral liquid (XRK). Methods: XRK (XRK group) and Weiqian Yinqiao tablets suspension (positive control group) were respectively given to the mice at a clinical dose of 30 0 and the acute toxicity was observed after 7 days. The rats were given 10 times the clinical dose (XRK low-dose group) and XRK (XRK high-dose group) for 10 days. The long-term toxicity of the mice was observed after 14 days of continuous administration. Results: In the acute toxicity test, there was no death in the XRK group and the blank control group after 7 days. The main tissues were basically normal while the death rate in the positive control group was 90%. The heart, liver and kidney of the main tissue were significantly damaged. In the long-term toxicity test No abnormality and death were found in the blank control group, XRK low dose group and XRK high dose group. Conclusion: Pediatric Relieving Oral Liquid is a safe and low toxic antipyretic drug than Vitamin C Yinqiao tablets.