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目的揭示本地区地中海贫血患儿出生相关因素,提出干预措施,为进一步制定我区地中海贫血预防控制总体规划提供决策参考。方法对我院近3年137例地贫儿(45例重型β-地贫、29例中间型β-地贫、32例中间型α-地贫和31例巴氏胎儿水肿综合征)出生相关因素进行调查研究。结果地贫儿出生相关社会心理因素顺位依次为:基因携带者不知情(70.07%),经济困难(21.17%),心理因素(5.11%),其它(3.65%)。基因携带者对自身情况不知情是本组地贫儿主要出生相关因素,与其它出生相关因素有显著差异(P<0.05)。结论基因携带者自身的认识与重视是预防控制工作的一个重要组成部分,地贫高发区人群携带者(轻型β-地贫、α-地贫特征和静止型携带者)的检出及系统管理是预防控制工作的关键环节,应进一步应用生物、社会及心理的医学模式搞好地贫预防控制工作。
Objective To reveal the related factors of birth in children with thalassemia in this region and to propose the intervention measures to provide a reference for the further development of the overall plan of thalassemia prevention and control in our district. Methods 137 cases of poor children (45 cases of severe β-thalassemia, 29 cases of β-thalassemia intermedia, 32 cases of intermediate α-thalassemia and 31 cases of Papulosis) were born in our hospital in recent 3 years Factors to investigate. Results The rank of social psychological factors related to the birth of thalassacity was: gene carrier without knowledge (70.07%), economic difficulty (21.17%), psychological factors (5.11%) and others (3.65%). Gene carriers do not know their own situation is the main source of geriatric impaired children related factors, and other birth-related factors were significantly different (P <0.05). Conclusion The carriers of gene carriers’ self-awareness and importance are an important part of prevention and control. The detection and system management of carriers (light β-thalassemia, α-thalassemia and resting carriers) in high thalassemia areas Is a key link in prevention and control. We should further apply biological, social and psychological medical models to do a good job in prevention and control of thalassemyat.