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应用电压敏感染料和光学记录方法研究大鼠皮层中自发癫痫状发放的起源过程.4AP可以诱发两种自发的癫痫状发放:间期发放和发作状发放.两种发放拥有相同的起源过程,都是起源于局部区域(单起源点,直径约400μm),然后传播到其他区域;两种发放的传播速度相同,都约为0.1m/s.但是两种发放的起源点的分布不同,间期发放的起源点呈分散分布,而发作状发放的起源点分布集中,呈簇集分布,间期发放和发作状发放起源点之间没有明显的时空联系.这些结果提示两种癫痫状发放可能是不同起因触发的相同过程.
Voltage-sensitive dyes and optical recording methods were used to investigate the origin of spontaneous epileptic delivery in the rat cortex.4 ASP can induce two spontaneous epileptiform delivery: interphase and paroxysmal delivery, both of which share the same origins Is originated in the local area (single origin point, with a diameter of about 400 μm) and then spreads to other areas; the velocities of the two treatments are the same at about 0.1 m / s, but the origins of the two treatments are distributed differently, The origins of the distribution were scattered, and the distribution of the origin of the distribution of seizures was centralized, with cluster distribution, and there was no obvious spatio-temporal relationship between the origin of seizures and the distribution of seizures.These results suggest that the two epileptic seizures may be The same process triggered by different causes.