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来自供应商的两群金黄地鼠,3周后发病,患增生性回肠炎(传染性回肠增生)。经细菌学和组织病理学检查估计第一组200只地鼠中有75只,第二组200只中有60只患有该病。所有出现增生性回肠炎临床症状的地鼠中都分离出空肠弯曲菌(以下简称“空弯菌”)。病原体从粪便和回肠中分离到。许多无症状的动物都有以增生性回肠炎为特征的组织病变,除一只地鼠外,其他所有地鼠都分离到空弯菌。从另一供应商获得的48只无病地鼠中没有分离到空弯菌。用下述方法之一:病回肠浸出物,1×10~8个/毫升活的空弯菌或灭菌生理盐水灌服接种地鼠。用回肠浸出物接种的8只地鼠中均分离出空弯菌,其中有5只有增生性回肠炎的临床症状。用纯培养物接种的地鼠发生空弯菌移生到回肠,但无回肠增生。以上这些资料以及空弯菌与动物和人的肠道疾病的相关性,提示了空弯菌是地鼠增生性回肠炎的病因。但另外的协同和诱发的因素也应包括在内。
Two groups of golden hamsters from a supplier developed disease after 3 weeks and had proliferative ileitis (infectious ileal hyperplasia). Bacteriological and histopathological examination estimated that 75 of the first group of 200 hamsters and 60 of the second group had the disease. Campylobacter jejuni is isolated from all hamsters presenting with clinical symptoms of proliferative ileitis (hereinafter referred to as “Campylobacter”). Pathogens are isolated from the stool and the ileum. Many asymptomatic animals have histopathological features that are characterized by proliferative ileitis, with the exception of one hamster, all hamsters having Bentley bacteria isolated. No Campylobacter was isolated from 48 diseased hamsters obtained from another supplier. Using one of the following methods: ileal ileum extract, 1 × 10 ~ 8 / ml of live Curcuma bacteria or sterile saline inoculated vaccination gopher. Campylobacter was isolated from 8 of the hamsters inoculated with ileum extracts, of which 5 had clinical symptoms of proliferative ileitis. Hamsters inoculated with pure cultures were transplanted to the ileum but not ileal hyperplasia. These data, as well as the correlation between Campylobacter and animal and human intestinal diseases, suggest that Campylobacter is the cause of hamster’s proliferative ileitis. However, additional synergistic and evoked factors should also be included.