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目的：研究十六角蒙脱石对大鼠急性胃粘膜损伤的防治作用。方法：４８只大鼠随机分为７个组，正常对照组、无水乙醇预防和治疗对照组、２个药物预防组、２个治疗组。其中预防组分别给予十六角蒙脱石０．１５ｇ／ｋｇ和雷尼替丁５ｍｇ／ｋｇｉｇ２次，再各ｉｇ无水乙醇０．７５ｍＬ／只；２个治疗组，先无水乙醇１ｍＬ／只ｉｇ，再分别给予十六角蒙脱石和雷尼替丁，每天剂量同上，ｉｇ１ｗｋ。结果：十六角蒙脱石无论是预防或治疗皆显著降低无水乙醇所致胃粘膜的损伤指数（ＩＩ），增加血流量，升高胃粘膜电位（ＰＤ），增加氨基己糖、磷脂含量和增强疏水性（Ｐ＜０．０１或＜０．０５）。而雷尼替丁治疗组仅对ＩＩ和ＰＤ有显著影响，结论：十六角蒙脱石是一种良好的胃粘膜防护剂。
Objective: To study the prevention and treatment of 16 montmorillonite on acute gastric mucosal lesion in rats. Methods: Forty eight rats were randomly divided into seven groups: normal control group, ethanol prevention and treatment control group, two drug prevention groups and two treatment groups. The prevention group were given montmorillonite hexahydrate 0.15g / kg and ranitidine 5mg / kgig2 times, and each ig ethanol 0.75mL / only; two treatment groups, first ethanol 1mL / only ig, and then were given hexagonal montmorillonite and ranitidine daily dose ibid., ig1wk. RESULTS: Hexadecalate montmorillonite significantly reduced gastric mucosal damage index (II) caused by ethanol, increased blood flow, increased gastric mucosal potential (PD), increased hexose hexose, and phospholipid content, both in prophylaxis and treatment And enhanced hydrophobicity (P <0.01 or <0.05). The ranitidine treatment group, only II and PD have a significant effect, Conclusion: 16 hexagonal montmorillonite is a good gastric mucosal protective agent.