目的 :研究 8 -甲氧基补骨脂素 (8-Methoxypsoralen ,8-MOP)、全反式维甲酸 (AllTransRetinoicAcid ,ATRA)以及两者联合应用对粘液表皮样癌高转移克隆细胞株 (The 3rdCloneofMucoepidermoidCarcinomaCellLine - 1,Mc3)细胞表皮生长因子受体 (EpidermalGrowthFactorReceptor,EGFR)表达的影响。 方法 :免疫组织化学染色方法。结果 :EGFR表达分别为 :对照组 (+ + ) ;8-MOP组 (+ ) ;ATRA(+ ) ;8-MOP与ATRA联合用药组 (+ )。结论 :处理以后的Mc3细胞的成瘤性及浸润播散能力可能下降 OBJECTIVE: To study the effect of 8-Methoxypsoralen (8-MOP) and all-trans retinoic acid (ATRA) on the expression of The 3rdClone of MucoepidermoidCarcinoma CellLine - 1, Mc3) on the expression of epidermal growth factor receptor (EGFR). Methods: Immunohistochemical staining method. Results: The expression of EGFR was: control group (+ +); 8-MOP group (+); ATRA (+); 8-MOP combined with ATRA group (+). Conclusion: The ability of tumorigenesis and infiltration of Mc3 cells after treatment may decline