论文部分内容阅读
目的:观察通管丸对大鼠的镇痛、改善微循环障碍的作用,并研究其急性毒性,以期为临床应用通管丸治疗输卵管阻塞性不孕症提供药效学依据。方法:采用大鼠足底注射福马尔林引起疼痛研究其镇痛作用;肾上腺素致大鼠肠系膜微循环障碍研究其改善微循环作用;同时进行急性毒性试验。结果:通管丸具有明显的外周镇痛、改善微循环障碍的药理作用,且口服未见明显急性毒性反应,拟用日剂量具有较高的安全性。结论:通管丸用于输卵管阻塞性不孕症,安全方便,值得临床推广。
OBJECTIVE: To observe the effect of Tong Guan Wan on analgesia in rats and to improve microcirculation, and to study its acute toxicity in order to provide a pharmacodynamic basis for the clinical application of Tong Guan Wan in the treatment of tubal obstruction infertility. Methods: Analgesia was induced by injecting formalin into the plantar site of rats. The effects of epinephrine on the mesenteric microcirculation in rats were studied. The microcirculation was improved. At the same time, the acute toxicity test was conducted. Results: Tong Guan Wan has obvious peripheral analgesia, improving the pharmacological effects of microcirculation disorders, and no obvious acute oral toxicity, the proposed daily dose with high safety. Conclusion: Tong Guan Wan for tubal obstruction infertility, safe and convenient, it is worth clinical promotion.