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目的探讨新生儿败血症病原学特点和分析致病菌耐药情况。方法分析无锡人民医院新生儿科285例新生儿败血症患儿培养检出菌及药敏实验结果情况。结果临床诊断败血症的血液标本中检出病原菌285株,其中G+245株(86.0%),G-40株(14.0%)。排在前五位的菌种是表皮葡萄球菌87株(30.5%)、溶血葡萄球菌49株(17.2%)、模仿葡萄球菌24株(8.4%)、金黄色葡萄球菌21株(7.4%)、大肠埃希菌18株(6.3%)。G+对青霉素G(90.0%)、苯唑西林(74.7%)、红霉素(74.3%)及氨苄西林(71.4%)耐药性高,对万古霉素、呋喃妥因未产生耐药(0.0%)。G-对氨苄西林(72.5%)耐药性高,对头孢哌酮/舒巴坦、亚胺培南及美罗培南未产生耐药(0.0%)。结论重视新生儿败血症病原菌耐药性检测,根据药敏结果选用敏感抗菌药物,可减少细菌耐药性的产生,提高临床治疗效果。
Objective To investigate the etiological characteristics of neonatal septicemia and analyze the pathogenic bacteria resistance. Methods The detection results of bacteria and drug sensitivity in 285 neonates with neonatal sepsis in Wuxi People’s Hospital were analyzed. Results A total of 285 pathogenic bacteria were detected in blood samples of clinically diagnosed sepsis, of which G + 245 (86.0%) and G-40 (14.0%) were detected. Staphylococcus epidermidis 87 (30.5%), Staphylococcus hemolyticus 49 (17.2%), Staphylococcus aureus 24 (8.4%), Staphylococcus aureus 21 (7.4%), 18 strains of Escherichia coli (6.3%). G + had high resistance to penicillin G (89.0%), oxacillin (74.7%), erythromycin (74.3%) and ampicillin (71.4%), but no resistance to vancomycin and nitrofurantoin (0.0% . G- was highly resistant to ampicillin (72.5%) and resistant to cefoperazone / sulbactam, imipenem and meropenem (0.0%). Conclusions Emphasis on the detection of drug resistance of neonatal sepsis pathogens, and the selection of sensitive antimicrobial agents based on drug susceptibility results in reducing bacterial drug resistance and improving clinical efficacy.