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目的分析并研究老年肝硬化合并门静脉血栓形成的临床特点,并对相关的危险因素进行分析。方法 66例肝硬化合并门静脉血栓形成的老年患者作为观察组,同期70例肝硬化不存在门静脉血栓形成的老年患者作为对照组。对两组患者的临床资料进行分析,探究相关危险因素。结果两组患者年龄、性别、国籍、病因、白细胞(WBC)、血小板(PLT)、国际标准化比值(INR)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、肌酐、总胆红素、脾静脉直径比较差异无统计学意义(P>0.05);两组患者D-二聚体、血红蛋白(Hb)、纤维蛋白降解产物(FDP)、门静脉内径、脾脏厚度、脾长、Child Pugh分级、脾切除比较差异具有统计学意义(P<0.05)。两组患者腹泻、肠梗阻、肝肾综合征、肝性脑病比较差异无统计学意义(P>0.05)。D-二聚体(OR=4.3064,P<0.05)和门静脉直径(OR=1.2547,P<0.05)是肝硬化门静脉血栓形成的独立危险因素。结论肝硬化的严重程度、D-二聚体、FDP水平、门静脉主干内径宽的患者,其合并门静脉血栓形成的发生率较高,门静脉主干内径增宽是导致肝硬化合并门静脉血栓形成的独立危险因素,提示临床上需要予以重视。
Objective To analyze and study the clinical characteristics of senile cirrhosis complicated with portal vein thrombosis and to analyze the related risk factors. Methods Sixty-six elderly patients with cirrhosis complicated by portal vein thrombosis were selected as the observation group and 70 elderly patients without portal vein thrombosis during the same period were selected as the control group. The clinical data of two groups of patients were analyzed to explore the relevant risk factors. Results The age, gender, nationality, etiology, white blood cell (WBC), platelet (PLT), INR, APTT, fibrinogen (FIB), creatinine, There was no significant difference in the diameter of spleen vein between the two groups (P> 0.05). D-dimer, hemoglobin (Hb), fibrin degradation product (FDP), diameter of portal vein, Pugh classification, splenectomy was statistically significant difference (P <0.05). Two groups of patients with diarrhea, intestinal obstruction, hepatorenal syndrome, hepatic encephalopathy was no significant difference (P> 0.05). D-dimer (OR = 4.3064, P <0.05) and portal vein diameter (OR = 1.2547, P <0.05) were independent risk factors for portal vein thrombosis in cirrhosis. Conclusions Patients with cirrhosis severity, D-dimer, FDP level and wide portal vein width have a higher incidence of portal vein thrombosis. The widening of the main portal vein diameter is an independent risk of cirrhosis with portal vein thrombosis Factors, suggesting that the clinical need to be taken seriously.