目的通过对出生缺陷发生情况进行分析,了解辽宁省5年间围产儿出生缺陷的现状及变化趋势,为制定干预措施提供科学依据。方法对2010年-2014年辽宁省监测医院分娩的围产儿进行出生缺陷监测,收集上报资料进行分析;结果5年间监测医院上报出生缺陷发生数6922例,出生缺陷平均发生率为91.4/万;出生缺陷顺位变化先天性心脏病、多指趾分别列第一、第二位,其他类型在不同年份有所不同;监测结果显示男性出生缺陷发生率高于女性,城市高于农村,年龄组出生缺陷儿发病率呈“U”型分布,差异均有统计学意义;结论加强孕前、孕期保健,并提高产前诊断水平,是降低出生缺陷发生率的有效措施。 Objective To analyze the status of birth defects and understand the status and trends of birth defects in perinatal children in Liaoning Province during the five years and provide a scientific basis for making interventions. Methods To monitor the birth defects of the perinatal infants born in Liaoning Provincial Monitoring Hospital from 2010 to 2014 and collect and submit the reported data for analysis. Results The number of birth defects reported by the monitoring hospitals in 5 years was 6922, the average incidence of birth defects was 91.4 / Defect rank change congenital heart disease, multi-digit toe were the first and second, the other types are different in different years; monitoring results show that the incidence of male birth defects than women, urban than in rural areas, the age group was born The incidence of defects was “U” type distribution, the differences were statistically significant; Conclusion Prenatal and prenatal care, and improve the level of prenatal diagnosis, is to reduce the incidence of birth defects effective measures.