论文部分内容阅读
[目的]探讨不同方案乙型肝炎疫苗免疫,对母亲HBsAg阳性新生儿的免疫持久性。[方法]在203名HBsAg阳性母亲的新生儿出生时,按不同方案和剂量注射乙型肝炎疫苗,免疫后5a内连续进行抗-HBs和HBsAg携带情况的追踪观察。[结果]5a内抗-HBs阳性率一直高于90％;新生儿免疫后抗-HBs在7个月～1岁形成高峰,在1～2岁期间下降了48.82％,2～6岁期间保持相对稳定;8例抗-HBs阴转后3～5a仍未被感染;14例抗-HBs阴转1～2a后又产生-HBs;无1例成为HBsAg携带者。[结论]乙型肝炎疫苗免疫后5～10a可不进行加强免疫。
[Objective] To investigate the immune persistence of HBsAg-positive newborns with different programs of hepatitis B vaccine. [Method] When the newborns of 203 HBsAg positive mothers were born, hepatitis B vaccine was injected according to different regimens and doses. The follow - up observation of anti - HBs and HBsAg were carried out consecutively within 5 days after immunization. [Results] The positive rate of anti-HBs was consistently higher than 90% within 5 years. The anti-HBs peaked at 7 months to 1 year after neonatal immunization, decreased by 48.82% at 1-2 years of age and maintained at 2-6 years 8 cases of anti-HBs have not been infected after 3 ~ 5 years of negative conversion; 14 cases of anti-HBs produced negative-1 to 2a-HBs; none of them became HBsAg carriers. [Conclusion] Hepatitis B vaccine can not be boosted 5 ~ 10 days after immunization.