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检测了35例急性白血病患者白细胞内谷胱甘肽过氧化物酶（GSH－PX）活力，同时用抗多药耐药P一糖蛋白单抗JSll－1检测了其中24例患者白细胞耐卜糖蛋白表达。结果显示：化疗前组白细胞内GSH－PX活力（106．28±15．81U）较正常对照组（8．38±7．42）明显增高（P＜0．05）；化疗后组白细胞内GSH－PX活力（125．21±17．75U）较化疗前组明显增高（P＜0．01）；检测24例化疗后患者P－糖蛋白表达16例表达阳性，其中11例疗效差；8例P－糖蛋白表达阴性，其中6例疗效差。P－糖蛋白表达阳性和阴性疗效差者GSH活力均增高。以上结果表明：急性白血病化疗耐药机制，P－糖蛋白高表达是一个较为重要的因素，但不是唯一的，GSH－PX活力增高可能是MDR形成的另一个重要原因。
The activity of glutathione peroxidase (GSH-PX) in white blood cells of 35 patients with acute leukemia was detected, and 24 patients with white blood cells were detected with anti-multidrug resistant P-glycoprotein monoclonal antibody JSll-1. Protein. The results showed that GSH-PX activity (106.28±15.81U) in leukocytes in the pre-chemotherapy group was significantly higher than that in the normal control group (8.38±7.42) (P<0.05); GSH in leukocytes after chemotherapy -PX activity (125.21±17.75U) was significantly higher than before chemotherapy (P<0.01); P-glycoprotein expression was positive in 16 patients after 24 cases of chemotherapy; 11 cases were poor; 8 cases Negative P-glycoprotein expression, of which 6 cases of poor efficacy. GSH activity was increased in patients with poor positive and negative P-glycoprotein expression. The above results indicate that the high expression of P-glycoprotein in acute leukemia is an important factor, but not the only one. The increase of GSH-PX activity may be another important reason for the formation of MDR.