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[目的]探讨煤矿工人消化性溃疡出血(PUB)患者的发病机制。[方法]对156例溃疡出血煤矿工人血脂(TC、TG、LDL-C、HDL-C)、血糖(FBS)、空腹胰岛素(FINS)和体重指数(BMI)水平进行检测,将结果与139例本矿健康体检职工(正常对照组)比较。[结果]PUB组的TC、TG和LDLC均值分别为(5.57±1.21)mmol/L,(1.56±1.64)mmol/L和(3.24±1.14)mmol/L,较正常对照组高(P﹤0.01),PUB组的HDLC均值为(1.36±0.48)mmol/L较正常对照组低(P﹤0.01);PUB组BMI升高、TC升高、TG升高和LDL-C升高的比例分别为19.9%、45.5%、17.3%和14.7%,较正常对照组高(P﹤0.01),HDL-C升高比例为34.6%,较正常对照组低(P﹥0.05),FBS和FINS均值分别为(4.93±0.71)mmol/L和(21.58±24.98)mmol/L,较正常对照组高(P﹤0.01),FBS和FINS升高的比例分别为16.6%和22.4%,也较正常对照组高(P﹤0.01)。[结论]煤矿工人PUB与代谢综合征(MS)可能是一个具有共同病理基础的源发于易感基因突变的多基因病,由于人群对易感基因易感程度的差异以及环境因素的影响,使得PUB和MS的临床表现形式多样化。
[Objective] To explore the pathogenesis of coal miners with peptic ulcer bleeding (PUB). [Methods] The levels of blood lipid (TC, TG, LDL-C, HDL-C), blood sugar (FBS), fasting insulin (FINS) and body mass index (BMI) were detected in 156 cases of ulcer hemorrhage. The mine health examination workers (normal control group) comparison. [Results] The average values of TC, TG and LDLC in PUB group were (5.57 ± 1.21) mmol / L and (1.56 ± 1.64) mmol / L and (3.24 ± 1.14) mmol / L, respectively ). The mean HDLC in PUB group was (1.36 ± 0.48) mmol / L lower than that in normal control group (P <0.01). The PUB group had higher BMI, higher TC, higher TG and higher LDL-C 19.9%, 45.5%, 17.3% and 14.7%, respectively, which was significantly higher than that of the normal control group (P <0.01). The increase of HDL-C was 34.6%, lower than that of the normal control group (4.93 ± 0.71) mmol / L and (21.58 ± 24.98) mmol / L respectively, which were significantly higher than those in normal control group (P <0.01). The rates of FBS and FINS were 16.6% and 22.4% higher than those in normal control group (P <0.01). [Conclusion] PUB and MS in coal miners may be a polygenic disease with common pathological basis and mutation originating in susceptible genes. Due to the difference of population susceptibility to susceptible genes and the influence of environmental factors, PUB and MS make the clinical manifestations of diversity.