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目的：探讨层粘蛋白（ＬＮ）、层粘蛋白受体（ＬＮ－Ｒ）及增殖细胞核抗原（ＰＣＮＡ）与原发性肝细胞癌（ＨＣＣ）恶性程度的关系。方法：采用ＳＡＢＣ法分别检测４２例肝细胞癌及癌旁组织中ＬＮ、ＬＮ－Ｒ及ＰＣＮＡ的表达情况。结果：ＬＮ、ＬＮ－Ｒ及ＰＣＮＡ在肝细胞癌中的表达均显著高于癌旁组织（Ｐ＜０．０５），且与肝细胞癌Ｅｄｍｏｎｄｓｏｎ分级呈正相关；浸润型（ＩＨＣＣ）生长、有转移、肿瘤直径＞３ｃｍ者ＬＮ、ＬＮ－Ｒ及ＰＣＮＡ的表达高，而膨胀型（ＥＨＣＣ）生长、无转移、肿瘤直径≤３ｃｍ者多表达较低；在高增殖指数组ＬＮ、ＬＮ－Ｒ表达高于低增殖指数组（Ｐ＜０．０５）。结论：细胞内ＬＮ、ＬＮ－Ｒ及ＰＣＮＡ可作为评判肝细胞癌恶性程度及临床预后的良好指标。
Objective: To investigate the relationship between laminin (LN), laminin receptor (LN-R), proliferating cell nuclear antigen (PCNA) and malignancy of primary hepatocellular carcinoma (HCC). Methods: The expressions of LN, LN-R and PCNA in 42 cases of hepatocellular carcinoma and adjacent normal tissues were detected by SABC method respectively. Results: The expressions of LN, LN-R and PCNA in hepatocellular carcinoma were significantly higher than those in paracancerous tissues (P <0.05), and were positively correlated with Edmondson grade of hepatocellular carcinoma. The infiltrating type (IHCC) , LN, LN-R and PCNA were higher in patients with tumor diameter> 3cm, while those in expanded type (EHCC) did not metastasize and the tumor diameter was less than 3cm. The expression of LN and LN-R in high proliferative index group was high In low proliferation index group (P <0.05). Conclusion: Intracellular LN, LN-R and PCNA can be used as a good indicator of malignancy and clinical prognosis of hepatocellular carcinoma.