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目的：研究恩其明醋酸盐（ＡＴ１８４０）在大鼠体内的药代动力学。方法：荧光检测法。结果：大鼠静注后，其体内的血药浓度－时间曲线符合二室开放模型。其分布相Ｔ１２α为０．５７ｍｉｎ，消除相Ｔ１２β为５．５１ｍｉｎ。大鼠ｉｖＡＴ１８４０后，组织中的药物浓度，以肺、肾浓度最高，肝、卵巢、心、脾、胃次之，肌肉、脂肪、脑中最低。尿中排泄量２４ｈ内占总给药量的２３．２８％；胆汁和粪中分别约为给药量的３６．４６％和１．７９％。ＡＴ１８４０与血浆蛋白的结合率６８．５％～７３．９％。结论：ＡＴ１８４０是一个血浆半衰期短，并有组织分布选择性的药物。
OBJECTIVE: To study the pharmacokinetics of enkind acetate (AT1840) in rats. Methods: Fluorescence detection method. Results: After intravenous injection in rats, the in vivo blood concentration-time curve conformed to the two-compartment open model. The distribution phase T12α was 0.57min and the elimination phase T12β was 5.51min. Rat ivAT1840, the concentration of the drug in the tissue, with the highest concentration of lung and kidney, the lowest in liver, ovary, heart, spleen, stomach, muscle, fat, brain. Urine excretion within 24 hours accounted for 23.28% of the total dose; bile and feces were about 36.46% and 1.79% of the dose. AT1840 and plasma protein binding rate of 68.5% to 73.9%. CONCLUSIONS: AT1840 is a short-acting, tissue-selective drug.