论文部分内容阅读
To investigate the effect of Spatholobus Suberectus Composita (SSC) on bone marrow hematopoiesis in child aplastic anemia (AA).Methods 31 cases of AA children were treated with SSC for 24 months. The pathological changes of bone marrow and the amount of CD_(34) positive cells before or after treatment were compared. 14 cases of normal volunteers were enrolled as control.Results The overall response rate was 87.1% (27 in 31 patients). The volume of nucleated cell in bone marrow (27.4±9.9vol% before treatment vs 44.6±31.5 vol% after treatment), granulocytes (36.0±9.9% vs 46.2±12.9%), megakaryocytes(3.3±7.2 vs 28.5±40.5 cells in bone marrow sections) and CD_(34)~+ cells (0.9±0.5% vs 2.0±0.7%) significantly increased after treatment compared with those before treatment (P<0.01 or P<0.05).Conclusion SSC has stimulative effect, which possibly acts at the level of stem/progenitor cells, on the bone marrow hematopoesis.
To investigate the effect of Spatholobus Suberectus Composita (SSC) on bone marrow hematopoiesis in child aplastic anemia (AA). Methods 31 AA of AA children were treated with SSC for 24 months. The pathological changes of bone marrow and the amount of CD 34 ) positive cells before or after treatment were compared. 14 cases of normal volunteers were enrolled as control. Results The overall response rate was 87.1% (27 in 31 patients). The volume of nucleated cells in bone marrow (27.4 ± 9.9 vol% before treatment vs 44.6 ± 31.5 vol% after treatment), granulocytes (36.0 ± 9.9 vs 46.2 ± 12.9%), megakaryocytes (3.3 ± 7.2 vs 28.5 ± 40.5 cells in bone marrow sections) and CD 34 (34 ± cells) 0.5% vs 2.0 ± 0.7%) significantly increased after treatment compared with those before treatment (P <0.01 or P <0.05) .Conclusion SSC has stimulative effect, which acts at the level of stem / progenitor cells, on the bone marrow hematopoesis .