【摘 要】
:
Chimeric antigen receptor-T (CAR-T) cells have limited therapeutic efficacy against solid tumors,partially due to their limited ability to reach and invade into
【机 构】
:
State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration
论文部分内容阅读
Chimeric antigen receptor-T (CAR-T) cells have limited therapeutic efficacy against solid tumors,partially due to their limited ability to reach and invade into the neoplastic foci.By gene expression profiling interactive analysis,we identified that the C-C motif chemokine ligand (CCL) 20 is highly expressed in lung and other most incidence and/or mortality cancers such as colon,rectum,stomach,and liver cancers.Forced expression of C-C motif chemokine receptor 6 (CCR6),the biunique receptor of CCL20,results in robust trafficking of CAR-T cells toward CCL20-secreting tumor cells.In a lung cancer xenograft mouse model,CCR6-expressing CAR-T cells efficiently migrate to and infiltrate into solid tumors upon infusion,leading to effective tumor clearance and significantly prolonged survival of tumor-bearing mice.In addition,culturing CCR6-CAR-T cells with interleukin (IL)-7 and IL-15 further improved their anti-lung cancer activity.Our findings provide supporting evidence for the clinical development of chemokine receptorengineered CAR-T cells for solid tumor immunotherapy.
其他文献
Retinitis pigmentosa (RP) is a form of inherited retinal degenerative diseases that ultimately involves the macula,which is present in primates but not in the r
Arid Central Asia(ACA),with its diverse landscapes of high mountains,oases,and deserts,hosted the cen-tral routes of the Silk Roads that linked trade centers fr
Confined low dimensional charges with high density such as two-dimensional electron gas (2DEG) at interfaces and charged domain walls in ferroelectrics show gre
Steels, accounting for a large proportion of metals and their alloys, are still irreplaceable structural materials in industrial applications for a long time.Cl
Synthesis of organosilanes from alkenes is a very important topic owing to their wide applications.A Ni/Cu dual metal-catalyzed arylsilylation of terminal alken
Fullerene-based electron-transporting layers (ETLs) significantly influence the defect passivation and device performance of inverted perovskite solar cells (PS
The ever-decreasing size of transistors requires effectively electrostatic control over ultra-thin semiconductor body.Rational design of the gate configuration
The development of sustainable energy is an effective way to solve the world energy shortage problem.Energy storage is of critical importance to the grid-scale
Electron-boson interaction is fundamental to a thorough understanding of various exotic properties emerging in many-body physics.In photoemission spectroscopy,p
A key requirement for well performing devices based on organic semiconductors is to ensure ohmic contacts, where an efficient hole and electron injection and ex