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两性霉素B在BMT中的应用较为广泛,但因其明显的肾毒性等副作用,使临床应用受到限制。据报道,两性霉素B与脂分子结合制成复方脂溶性两性霉素B(ABLC)可明显降低肾毒性等副作用。本文评价了ABLC用于治疗BMT受者严重真菌感染的有效性及安全性。 95例临床怀疑或已证实真菌感染的BMT患者接
Amphotericin B is widely used in BMT, but its clinical application is limited because of its obvious side effects such as nephrotoxicity. It has been reported that the combination of amphotericin B and lipid molecules made of compound lipophilic amphotericin B (ABLC) can significantly reduce side effects such as renal toxicity. This article assesses the usefulness and safety of ABLC in the treatment of severe fungal infections in BMT recipients. 95 cases of clinically suspected or confirmed fungal infection in patients with BMT access