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目的:探讨n 18F-脱氧葡萄糖(FDG)PET在评估先天性心脏病相关肺动脉高压(PAH-CHD)患者的肺组织葡萄糖摄取速率及其与肺动脉血流动力学指标间关系中的价值。n 方法:回顾性纳入阜外医院2018年1月至2019年6月间16例PAH-CHD患者[男6例，女10例，年龄(29.2±10.6)岁]和22名健康体格检查者[对照组；男8名，女14名，年龄(45.4±3.8)岁]。2组均行动态n 18F-FDG PET检查，测定双肺n 18F-FDG摄取速率(以Ki表示)，显像1周内PAH-CHD组接受右心导管检查测定平均肺动脉压力、肺血管阻力等。采用两独立样本n t检验比较2组Ki，采用Pearson相关分析PAH-CHD组Ki与平均肺动脉压力和肺血管阻力的相关性。n 结果:PAH-CHD患者双肺Ki高于对照组，2组Ki分别为(0.000 6±0.000 3)和(0.000 4±0.000 3) ml·gn -1·minn -1(n t＝2.15, n P＝0.038)；但PAH-CHD患者Ki与肺血管阻力[(10.86±4.45) Wood单位]和平均肺动脉压力[(69.75±18.93) mmHg；1 mmHg＝0.133 kPa]均未见相关性(n r值：0.202和0.006，均n P>0.05)。n 结论:18F-FDG PET能对PAH-CHD患者肺血管重构导致的肺组织葡萄糖摄取进行有效监测，对PAH-CHD肺血管重构的评估可能具有潜在价值。n “,”Objective:To investigate the value of n 18F-fluorodeoxyglucose (FDG) PET imaging in evaluating the n 18F-FDG influx rate of lungs and its relationship with parameters of pulmonary hemodynamics in patients with pulmonary arterial hypertension related to congenital heart disease (PAH-CHD).n Methods:From January 2018 to June 2019, a total of 16 PAH-CHD patients (6 males, 10 females, age (29.2±10.6) years) and 22 health controls who received physical examinations (8 males, 14 females, age (45.4±3.8) years) in Fuwai Hospital were respectively enrolled. All cases underwent dynamic n 18F-FDG PET imaging for whole lung n 18F-FDG influx rate (presented as Ki). Right heart catheterization was performed to evaluate pulmonary hemodynamic parameters such as pulmonary vascular resistance (PVR), mean pulmonary vascular pressure (mPAP) in PAH-CHD patients after imaging within one week. Independent-sample n t test was used to compare Ki of 2 groups, and Pearson correlation analysis was used to analyze the relationship between Ki and PVR, mPAP in PAH-CHD patients.n Results:Ki of the lungs was significantly higher in PAH-CHD patients than that in controls ((0.000 6±0.000 3) n vs (0.000 4±0.000 3) ml·gn -1·minn -1; n t=2.15, n P=0.038). Ki was not correlated with PVR ((10.86±4.45) Wood units) or mPAP ((69.75±18.93) mmHg; 1 mmHg=0.133 kPa) in PAH-CHD patients (n r values: 0.202 and 0.006, both n P>0.05).n Conclusions:Pulmonary vascular remodeling can lead the increasing lung n 18F-FDG uptake in patients with PAH-CHD. n 18F-FDG PET may have the ability in monitoring and evaluating pulmonary vascular remodeling in PAH-CHD.n