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脓毒症是指严重的全身感染所引起的宿主免疫反应所导致的危及生命的器官功能障碍,自提出概念以来,脓毒症以及严重的全身感染一直是造成ICU病人死亡的重要原因。研究表明,巨噬细胞作为促炎细胞因子IL-6、IL-1β及TNF-α的重要来源在脓毒症的发生中起着重要的作用。巨噬细胞通过经典和非经典途径-caspase-11等炎性Caspase介导的非经典炎性体途径是巨噬细胞对多种危险因素,尤其是革兰阴性菌的识别与处理的重要途径,同时在促炎细胞因子的释放,免疫细胞焦亡以及病原体清除等方面发挥着重要作用。本文重点回顾了近年来非经典炎性体通路在脓毒症中的作用的研究进展。
Sepsis is a life-threatening organ dysfunction caused by a host immune response caused by a severe systemic infection. Sepsis and severe systemic infections have been the major cause of death in ICU patients since the concept was proposed. Studies have shown that macrophages play an important role in the pathogenesis of sepsis as an important source of proinflammatory cytokines IL-6, IL-1β and TNF-α. Macrophages through the classical and non-classical pathway - caspase-11 and other inflammatory caspases mediate the non-classical inflammatory pathways of macrophages for a variety of risk factors, especially gram-negative bacteria, an important way to identify and deal with, It also plays an important role in the release of proinflammatory cytokines, focal death of immune cells and pathogen clearance. This review focuses on the recent advances in the role of non-classical inflammasome pathways in sepsis.