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目的 :通过对诺氟沙星 -聚维酮 (FPA- PVP)共沉淀物在人体内药物动力学考察 ,为临床用药提供理论参考。 方法 :采用单剂量口服给药的方式 ,采用尿药速率法求药物动力学参数。 结果 :FPA- PVP共沉淀物的相对生物利用度为 16 2 .2 6 %。 结论 :将难溶性药物制成以亲水性高分子材料为载体的共沉淀物 ,对于提高难溶性药物的生物利用度是有效的方法之一。
OBJECTIVE: To investigate the pharmacokinetics of norfloxacin-Povidone (FPA-PVP) co-precipitate in human body and provide a theoretical reference for clinical use. Methods: A single oral dose of the drug was used to determine the pharmacokinetic parameters using urinary drug rate method. Results: The relative bioavailability of FPA-PVP coprecipitate was 16.2.26%. Conclusion: It is an effective method to improve the bioavailability of poorly soluble drug by making the poorly soluble drug into a coprecipitate with hydrophilic polymer as the carrier.