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美国报道重组体干扰素α对慢性C型肝炎至少暂时阻止肝损坏的进展。 166例慢性C型肝炎分为大剂量组、小剂量组和对照组。24周后大剂量组的血清丙氨酸转氨酶有45％患者降低或接近正常,小剂量组为28％。而对照组仅有8％,干扰素生化特性约在一半病例中存留6个月才衰退。研究中每周注射3次,每次10万和30万单位,活检证明大剂量者一半有改善,小剂量者为1/4。小剂量者中1/4有类似流感的副反应,大剂量者有1/4～1/3腹泻或轻度脱发。
The United States reported that recombinant interferon alpha has at least temporarily halted the progression of liver damage in chronic hepatitis C. 166 cases of chronic hepatitis C were divided into high-dose group, low-dose group and control group. After 24 weeks, 45% of the serum alanine aminotransferases in the high-dose group were reduced or nearly normal, compared to 28% in the low-dose group. Compared with only 8% in the control group, and biochemical characteristics of interferon remained decayed for about 6 months in about half of the cases. Study injections three times a week, each 100,000 and 300,000 units, biopsy proved that half of the large dose to improve, small doses were 1/4. One-fourth of the patients in the low-dose group had side effects similar to those of the flu, with 1 / 4-1 / 3 of high doses having diarrhea or mild hair loss.