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甘丙肽（galanin,GAL）是一种广泛分布在神经系统的神经肽,具有广泛的神经生物学功能。主要参与下丘脑神经内分泌调节,与摄食行为密切相关,对学习和记忆有明显抑制作用。海马中GAL免疫活性细胞极少,但海马接受大量来自隔区、蓝斑及下丘脑的GAL免疫活性纤维投射。海马内的GAI通过抑制海马CAI区锥体细胞的兴奋性突触后电位,抑制兴奋性氨基酸的释放,开放ATP依赖性K+通道而发挥其抗癫(?)作用。遗传诱导的GAL表达变化可调节海马的兴奋性从而决定癫(?)发作的倾向。
Galanin (GAL) is a neuropeptide that is widely distributed in the nervous system and has a wide range of neurobiological functions. Mainly involved in hypothalamic neuroendocrine regulation, and feeding behavior is closely related to learning and memory significantly inhibited. The GAL-immunoreactive cells in the hippocampus are rare, but the hippocampus receives a large number of GAL immunoreactive fiber projections from the septum, the locus coeruleus, and the hypothalamus. GAI in the hippocampus exerts its antiepileptic effect by inhibiting the excitatory postsynaptic potential of the pyramidal cells in the hippocampal CA1 pyramidal cells, inhibiting the release of excitatory amino acids and opening up the ATP-dependent K + channel. Genetically-induced changes in GAL expression regulate the excitability of the hippocampus and thus the propensity for epileptic attacks.