给正常豚鼠喂饲大量胆固醇所引起的高脂类血症,可因同时给予大量维生素C而得到明显减轻,使血中胆固醇与磷脂的比值恢复正常,明显降低肝内胆固醇及甘油三酯的蓄积,并使主动脉壁内胆固醇的沉积与正常对照组无明显差异。另外本实验中还观察到给豚鼠大量胆固醇能使肝内维生素C的含量明显减少,从而说明维生素C与胆固醇代谢有密切关系。最后本文关于维生素C对胆固醇代谢作用机制进行了简短的讨论。 Hyperlipidemia caused by feeding a large amount of cholesterol to normal guinea pigs can be significantly reduced due to the simultaneous administration of a large amount of vitamin C to normalize the ratio of cholesterol to phospholipid in the blood and significantly reduce the accumulation of intrahepatic cholesterol and triglyceride , And the aortic wall cholesterol deposition and no significant difference between the normal control group. In addition, this experiment also observed that a large number of guinea pig cholesterol can significantly reduce the content of vitamin C in the liver, which shows that vitamin C and cholesterol metabolism are closely related. Finally, this article on vitamin C cholesterol metabolism mechanism for a brief discussion.