继青霉素、头孢菌素以后在七十年代又发现了棒酸、诺卡菌素和硫霉素等具有β-内酰胺环结构的抗生素或β-内酰胺酶抑制剂。近几年来,又发现了一些单环S-内酰胺抗生素并合成了氨噻羧单胺菌素(Azthreonam,SQ26,776)等许多抗菌作用强的单环β-内酰胺类化合物。这些发现引起人们对β-内酰胺类化合物的极大兴趣。现在有关 Subsequent to penicillin, cephalosporin and later in the seventies also found clavulanic acid, nocardin and thiophanmycin and other β-lactam ring structure of antibiotics or β-lactamase inhibitors. In recent years, some monocyclic S-lactam antibiotics have also been found and many antibacterial monocyclic β-lactams have been synthesized, such as azthreonam (SQ26,776). These findings have drawn great interest in β-lactam compounds. Now relevant