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探讨婴幼儿肺炎患儿血浆免疫活性内皮素-1（irET－1）水平与肺动脉高压之间的关系。方法对17例对照组、38例轻型肺炎及10例重型肺炎极期和恢复期测定血浆irET-1水平，以多普勒超声心动图测定指标估测肺动脉压。结果1．婴幼儿肺炎极期存在肺动脉高压，重型肺炎组重于轻型肺炎组。2．重型肺炎极期血浆irET-1升高，并与肺动脉压力是显著正相关。3．缺氧是导致血浆irET-1升高的主要原因，重型肺炎极期血浆irET-1与血氧分压呈负相关。结论婴幼儿肺炎极期缺氧可能导致内源性ET合成与释放的增加，进而引起肺动脉高压。
To investigate the relationship between plasma level of irET-1 and pulmonary hypertension in infants and children with pneumonia. Methods Plasma irET-1 levels were measured in 17 patients in control group, 38 patients with mild pneumonia and 10 patients with severe pneumonia in both polar and convalescent phases. Pulmonary arterial pressure was assessed by Doppler echocardiography. Results 1. Pneumonia in infants and young children is very high in pulmonary hypertension, severe pneumonia group is more than mild pneumonia group. 2. In severe pneumonia, the plasma level of irET-1 was increased at a very early stage and was significantly and positively correlated with pulmonary artery pressure. 3. Hypoxia is the main reason leading to the increase of plasma irET-1. The plasma level of irET-1 in severe pneumonia is negatively correlated with partial pressure of blood oxygen. Conclusions Extreme hypoxia in infantile pneumonia may result in the increase of synthesis and release of endogenous ET, leading to pulmonary hypertension.